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I have fixed incorrect usage of these flags in some files (see r13827).
I have NOT changed env_settings.xrc, as the discussion is still alive.

Correspondingly, when using a horizontal sizer, each child can be centered, aligned at the bottom or aligned at the top.
<object class="sizeritem">
<object class="wxBoxSizer">
<object class="sizeritem">
<object class="wxStaticText" name="wxID_ANY">
<label>Select application appearance (if supported by platform):</label>
</object>
<flag>wxLEFT|wxRIGHT|wxALIGN_CENTER_HORIZONTAL|wxALIGN_CENTER_VERTICAL</flag>
<border>4</border>
</object>
<object class="sizeritem">
<object class="wxChoice" name="chAppearance">
<content>
<item>System default</item>
<item>Dark</item>
<item>Light</item>
</content>
<selection>0</selection>
<enabled>0</enabled>
</object>
<flag>wxALIGN_CENTER_VERTICAL</flag>
<border>4</border>
<option>1</option>
</object>
</object>
<flag>wxEXPAND</flag>
<border>4</border>
</object>