I would like to ask for an extra setup step. The moment you have specified that you want a debug and release target, and you specified the wx (eg by #wx), then in most cases people will get the warning that the debug buld will not be able to build because no 'debug' configuration can be found for wx.
I would suggest that in the case it is not found, and in the case such a wx debug config exist, the user is notified of the possible choices so he can pick one. Why, for many cases I assume people want a debug and release target of their project (debug fo debugging and release for optimized release build), without actually caring about a debug wx configuration. [Just like we develop CB very often with a wx release config, but nevertheless we build a CB debug version].
So when the user says he wants a debug target, present an (advanced) option to specify if he wants to use a wx debug configuration (suggestion : default ; debug/release both use the release configuration of wx), and only when the user chooses to use the wx debug configuration and it is not present throw a warning/error message.
Just my little 5 cents ;-)