Hello,
Is it possible to have a single project to support multiple compiler configurations for build targets?
Yes.
You can chose different compilers for each target.
Just right-click your project, click on build options and change the compiler on the target level.
I have cross-compiling targets with "normal" gcc for linux and i586mingw32-cross-compiler for windows builds, they all share the same (wxwidgets)-project, but have different target-specific settings (calls to wx-config, library search-paths etc.)