1) Have you tried the project wizard to create a wxWidgets project? There should not be any work to do once the wizard completed
2) I think you have put the options in the wrong place:
Compiler options:
Project->Build options-> select the project name on the right->Compiler Settings->Other compiler options:
`/usr/local/bin/wx-config --cxxflags`
Linker options:
Project->Build options->select the project name on the right->Linker settings->Other linker options:
`/usr/local/bin/wx-config --libs`